11 Facts About Fingernails

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Whether there's dirt beneath them or polish atop them, your fingernails serve more than just decorative purposes: They help keep your fingertips safe and have a multitude of special functions that even your doctor might not be aware of. “The nails occupy a unique space within dermatology and medicine in general, particularly because they are such a niche area about which few people have expertise,” Evan Rieder, assistant professor in the Ronald O. Perelman Department of Dermatology at NYU Langone Health, tells Mental Floss.

1. FINGERNAILS HAVE FOUR MAIN PARTS.

Along with skin and hair, nails are part of the body's integumentary system, whose main function is to protect your body from damage and infection. Fingernails have four basic structures: the matrix, the nail plate, the nail bed, and the skin around the nail (including the cuticle).

Fingernail cells grow continuously from a little pocket at the root of the nail bed called the matrix. The pale, crescent-shaped lunula—derived from Latin for "little moon"—on the nail itself is the visible portion of the matrix. If the lunula is injured, the  nail won't grow normally (a scarred lunula can result in a split nail), and changes in the lunula's appearance can also be signs of a systemic disease.

Fingernail cells are made of a protein called keratin (same as your hair). As the keratin cells push out of the matrix, they become hard, flat and compact, eventually forming the hard surface of the nail known as the nail plate. Beneath that is the nail bed, which almost never sees the light of day except when there's an injury or disease.

Surrounding the matrix is the cuticle, the semi-circle of skin that has a tendency to peel away from the nail. The skin just underneath the distal end of the fingernail is called the hyponychium, and if you've ever trimmed your nails too short, you know this skin can be slightly more sensitive than the rest of the fingertip.

2. THEY GROW AT A RATE OF 0.1 MILLIMETERS A DAY ...

That's about 3 to 4 millimeters per month. But they don't always grow at the same speed: Fingernails grow more quickly during the day and in summer (this may be related to exposure to sunlight, which produces more nail-nourishing vitamin D). Nails on your bigger fingers also grow faster, and men's grow faster than women's. The pinky fingernail grows the slowest of all the fingernails. According to the American Academy of Dermatology, if you lose a fingernail due to injury, it can take up to six months to grow back (while a toenail could take as much as a year and a half).

3. ... BUT NOT AFTER YOU'RE DEAD.

You've probably heard that your fingernails keep growing after death. The truth is, they don't, according to the medical journal BMJ. What's actually happening is that the skin around the base of the fingernails retracts because the body is no longer pumping fluids into the tissues, and that creates a kind of optical illusion that makes the nails appear longer.

4. ITS ESTIMATED THAT 20 TO 30 PERCENT OF PEOPLE BITE THEIR NAILS.

Scientists say it's still unclear why, but they suspect nail-biters do it because they're bored, frustrated, concentrating, or because it just feels comforting (and anxiety doesn't seem to play a big role). Perfectionists who don't like to be idle are very likely to have the habit. Biters expose themselves to the dangerous crud that collects underneath the nail: The hyponychium attracts bacteria, including E. coli, and ingesting that through nail-biting can lead to gastrointestinal problems down the line. Biting can also damage teeth and jaws.

5. HUMAN FINGERNAILS ARE BASICALLY FLAT CLAWS.

Our primate ancestors had claws—which, like nails, are made of keratin. As human ancestors began using tools some 2.5 million years ago (or even earlier), evolutionary researchers believe that curved claws became a nuisance. To clutch and strike stone tools, our fingertips may have broadened, causing the claws to evolve into fingernails.

6. THE NAIL ACTUALLY MAKES YOUR FINGERTIP MORE SENSITIVE.

While the fingernail may be tough enough to protect tender flesh, it also has the paradoxical effect of increasing the sensitivity of the finger. It acts as a counterforce when the fingertip touches an object. "The finger is a particularly sensitive area because of very high density of nerve fibers," Rieder says.

7. FINGERNAILS CAN REVEAL LUNG, HEART, AND LIVER DISEASES.

"One of the most interesting facts about fingernails is that they are often a marker for disease within the body," Rieder says. Nail clubbing—an overcurvature of the nail plate and thickening of the skin around the nails—is a particularly significant sign of underlying illness, such as lung or heart disease, liver disease, or inflammatory bowel disease. Two-toned nails—whitish from the cuticle to the nail's midpoint and pink, brown, or reddish in the distal half—can be a sign of kidney and liver disease. Nails that are two-thirds whitish to one-third normal can also be a sign of liver disease. However, little white marks on your nails, known as milk spots (or punctate leukonychia) are just the remnants of any kind of trauma to the nail, from slamming it in a door to chewing on it too fervently.

8. YOU CAN GET A COMMON SKIN DISEASE ON YOUR NAILS.

Psoriasis is "typically thought of as a skin disease, but is actually a skin, joint, and nail disease, and when severe, a marker of cardiovascular risk," Rieder says. Psoriatic fingernails may have orange patches called oil spots, red lines known as splinter hemorrhages, lifting of the edges of the nails, and pits, "which look like a thumb tack was repeatedly and haphazardly pushed into the nails," he says.

Doctors often prescribe topical or injected corticosteroids to treat psoriatic nails, but using lasers is an emerging and potentially more cost-effective technique. Rieder relies on a pulsed dye laser, which uses an organic dye mixed with a solvent as the medium to treat nail psoriasis, "which can be both medically and aesthetically bothersome," he says. This laser is able to penetrate through the hard nail plate with minimal discomfort and "to treat targets of interest, in the case of psoriasis, blood vessels, and hyperactive skin," Rieder says.

9. ANCIENT CULTURES DISPLAYED SOCIAL STATUS WITH NAIL ART.

Painting and other forms of decorating nails have a history of offering social and aesthetic cues through variations in nail color, shape, and length, Rieder says. In fact, he adds, in some cultures ornate and well-decorated fingernails "serve as a proxy for social status."

Five thousand years ago in China, men and women of the Ming Dynasty aristocracy grew their nails long and covered them with golden nail guards or bright home-made polishes. The long nails allegedly announced to the world their social rank and their freedom from performing menial labor.

10. A FORMER BEAUTICIAN HELD THE WORLD RECORD FOR THE LONGEST NAILS.

Lee Redmond of Utah started growing her nails in 1979 and kept at it until she held the world record for "longest fingernails on a pair of hands ever (female)" in 2008. Her right thumbnail was 2 feet, 11 inches and the collective length of all her nails was 28 feet, 4 inches. She also applied nail hardener daily and painted them a reflective gold. Unfortunately, she broke her nails in a 2009 car accident and has no plans to regrow them.

More recently, the man who holds the Guinness record for the "longest fingernails on a single hand—ever" chose to chop them off at Ripley's Believe It Or Not! in New York City in July 2018. Shridhar Chillal of Pune, India started growing the nails of his left hand in 1952, when he was 14 years old. At last count, the total length measured 29 feet, 10.1 inches.

11. THE FIRST NAIL CLIPPERS WERE PATENTED IN 1875.

Today, biters don't have to use their teeth to trim their nails. While the earliest tools for cutting nails were most likely sharp rocks, sand, and knives, the purpose-built nail clipper—though it might be more accurately called a circular nail file—was designed by a Boston, Massachusetts inventor named Valentine Fogerty and patented in 1875. The nail clippers we know today were the design of inventors Eugene Heim and Oelestin Matz, who were granted their patent for a clamp-style fingernail clipper in 1881.

‘Water’ in Kansas City Woman’s Ear Turned Out to Be a Venomous Brown Recluse Spider

N-sky/iStock via Getty Images
N-sky/iStock via Getty Images

Susie Torres, a resident of Kansas City, Missouri, woke up on Tuesday morning with the distinct feeling that water was lodged in her left ear. She likened it to the swooshing sensation that can often happen after swimming, WDAF-TV reports.

Instead of waiting for the problem to resolve itself, Torres went to the doctor—a decision that might have saved her from some serious pain. The medical assistant was the first to realize something was alarmingly amiss, and immediately called for backup.

“She ran out and said ‘I’m going to get a couple more people,’” Torres told 41 Action News. “She then said, ‘I think you have an insect in there.’” For many people, the thought of having any live insect stuck in an ear would be enough to cue a small- or large-scale freak-out, but Torres stayed calm.

The doctors “had a few tools and worked their magic and got it out,” Torres said. The “it” in question turned out to be a spider—and not just any harmless house spider (which you shouldn’t kill, by the way). It was a venomous brown recluse spider.

“Gross,” Torres told WDAF-TV. “Why, where, what, and how.”

Miraculously, the spider didn’t bite Torres. If it had, she would’ve ended up visiting the doctor with more than general ear discomfort: Brown recluse bites can cause pain, burning, fever, nausea, and purple or blue discoloration of the surrounding skin, according to Healthline.

Torres may have remained admirably level-headed throughout the ordeal, but that doesn’t mean she’s taking it lightly. “I went and put some cotton balls in my ears last night,” she told WDAF-TV. “I’m shaking off my clothes, and I don’t put my purse on the floor. I’m a little more cautious.”

Is this the first time an insect has posted up in the ear of an unsuspecting, innocent human? Absolutely not—here are six more horror stories, featuring a cockroach, a bed bug, and more.

[h/t WDAF-TV]

12 Fantastic Facts About the Immune System

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monkeybusinessimages/iStock via Getty Images

If it weren't for our immune system, none of us would live very long. Not only does the immune system protect us from external pathogens like viruses, bacteria, and parasites, but it also battles cells that have mutated due to illnesses, like cancer, within the body. Here are 12 fascinating facts about the immune system.

1. The immune system saves lives.

The immune system is a complex network of tissues and organs that spreads throughout the entire body. In a nutshell, it works like this: A series of "sensors" within the system detects an intruding pathogen, like bacteria or a virus. Then the sensors signal other parts of the system to kill the pathogen and eliminate the infection.

"The immune system is being bombarded by all sorts of microbes all the time," Russell Vance, professor of immunology at University of California, Berkeley and an investigator for the Howard Hughes Medical Institute, tells Mental Floss. "Yet, even though we're not aware of it, it's saving our lives every day, and doing a remarkably good job of it."

2. Before scientists understood the immune system, illness was chalked up to unbalanced humors.

Long before physicians realized how invisible pathogens interacted with the body's system for fighting them off, doctors diagnosed all ills of the body and the mind according to the balance of "four humors": melancholic, phlegmatic, choleric, or sanguine. These criteria, devised by the Greek philosopher Hippocrates, were divided between the four elements, which were linked to bodily fluids (a.k.a. humors): earth (black bile), air (blood), water (phlegm) and fire (yellow bile), which also carried properties of cold, hot, moist, or dry. Through a combination of guesswork and observation, physicians would diagnose patients' humors and prescribe treatment that most likely did little to support the immune system's ability to resist infection.

3. Two men who unraveled the immune system's functions were bitter rivals.

Two scientists who discovered key functions of the immune system, Louis Pasteur and Robert Koch, should have been able to see their work as complementary, but they wound up rivals. Pasteur, a French microbiologist, was famous for his experiments demonstrating the mechanism of vaccines using weakened versions of the microbes. Koch, a German physician, established four essential conditions under which pathogenic bacteria can infect hosts, and used them to identify the Mycobacterium tuberculosis bacterium that causes tuberculosis. Though both helped establish the germ theory of disease—one of the foundations of modern medicine today—Pasteur and Koch's feud may have been aggravated by nationalism, a language barrier, criticisms of each other's work, and possibly a hint of jealousy.

4. Specialized blood cells are the immune system's greatest weapon.

The most powerful weapons in your immune system's arsenal are white blood cells, divided into two main types: lymphocytes, which create antigens for specific pathogens and kill them or escort them out of the body; and phagocytes, which ingest harmful bacteria. White blood cells not only attack foreign pathogens, but recognize these interlopers the next time they meet them and respond more quickly. Many of these immune cells are produced in your bone marrow but also in the spleen, lymph nodes, and thymus, and are stored in some of these tissues and other areas of the body. In the lymph nodes, which are located throughout your body but most noticeably in your armpits, throat, and groin, lymphatic fluid containing white blood cells flows through vein-like tubules to escort foreign invaders out.

5. The spleen helps your immune system work.

Though you can live without the spleen, an organ that lies between stomach and diaphragm, it's better to hang onto it for your immune function. According to Adriana Medina, a doctor who specializes in hematology and oncology at the Alvin and Lois Lapidus Cancer Institute at Sinai Hospital in Baltimore, your spleen is "one big lymph node" that makes new white blood cells and cleans out old blood cells from the body.

It's also a place where immune cells congregate. "Because the immune cells are spread out through the body," Vance says, "eventually they need to communicate with each other." They do so in both the spleen and lymph nodes.

6. You have immune cells in all of your tissues.

While immune cells may congregate more in lymph nodes than elsewhere, "every tissue in your body has immune cells stationed in it or circulating through it, constantly roving for signs of attack," Vance explains. These cells also circulate through the blood. The reason for their widespread presence is that there are thousands of different pathogens that might infect us, from bacteria to viruses to parasites. "To eliminate each of those different kinds of threats requires specialized detectors," he says.

7. How friendly you're feeling could be linked to your immune system.

From an evolutionary perspective, humans' high sociability may have less to do with our bigger brains, and more to do with our immune system's exposure to a greater number of bacteria and other pathogens.

Researchers at the University of Virginia School of Medicine have theorized that interferon gamma (IG), a substance that helps the immune system fight invaders, was linked to social behavior, which is one of the ways we become exposed to pathogens.

In mice, they found IG acted as a kind of brake to the brain's prefrontal cortex, essentially stopping aberrant hyperactivity that can cause negative changes in social behavior. When they blocked the IG molecule, the mice's prefrontal cortexes became hyperactive, resulting in less sociability. When they restored the function, the mice's brains returned to normal, as did their social behavior.

8. Your immune system might recruit unlikely organs, like the appendix, into service.

The appendix gets a bad rap as a vestigial organ that does nothing but occasionally go septic and create a need for immediate surgery. But the appendix may help keep your gut in good shape. According to Gabrielle Belz, professor of molecular immunology at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, research by Duke University's Randal Bollinger and Bill Parker suggests the appendix houses symbiotic bacteria that are important for overall gut health—especially after infections wipe out the gut's good microbes. Special immune cells known as innate lymphoid cells (ILCs) in the appendix may help to repopulate the gut with healthy bacteria and put the gut back on track to recovery.

9. Gut bacteria has been shown to boost immune systems in mice.

Researchers at the University of Chicago noticed that one group of mice in their lab had a stronger response to a cancer treatment than other mice. They eventually traced the reason to a strain of bacteria—Bifidobacterium—in the mice's guts that boosted the animals' immune system to such a degree they could compare it to anti-cancer drugs called checkpoint inhibitors, which keep the immune system from overreacting.

To test their theory, they transferred fecal matter from the robust mice to the stomachs of less immune-strengthened mice, with positive results: The treated mice mounted stronger immune responses and tumor growth slowed. When they compared the bacterial transfer effects with the effects of a checkpoint inhibitor drug, they found that the bacteria treatment was just as effective. The researchers believe that, with further study, the same effect could be seen in human cancer patients.

10. Scientists are trying to harness the immune system's "Pac-Man" cells to treat cancer.

Aggressive pediatric tumors are difficult to treat due to the toxicity of chemotherapy, but some researchers are hoping to develop effective treatments without the harmful side effects. Stanford researchers designed a study around a recently discovered molecule known as CD47, a protein expressed on the surface of all cells, and how it interacts with macrophages, white blood cells that kill abnormal cells. "Think of the macrophages as the Pac-Man of the immune system," Samuel Cheshier, lead study author and assistant professor of neurosurgery at Stanford Medicine, tells Mental Floss.

CD47 sends the immune system's macrophages a "don't eat me" signal. Cancer cells fool the immune system into not destroying them by secreting high amounts of CD47. When Cheshier and his team blocked the CD47 signals on cancer cells, the macrophages could identify the cancer cells and eat them, without toxic side effects to healthy cells. The treatment successfully shrank all five of the common pediatric tumors, without the nasty side effects of chemotherapy.

11. A new therapy for type 1 diabetes tricks the immune system.

In those with type 1 diabetes, the body attacks its own pancreatic cells, interrupting its normal ability to produce insulin in response to glucose. In a 2016 paper, researchers at MIT, in collaboration with Boston's Children's Hospital, successfully designed a new material that allows them to encapsulate and transplant healthy pancreatic "islet" cells into diabetic mice without triggering an immune response. Made from seaweed, the substance is benign enough that the body doesn't react to it, and porous enough to allow the islet cells to be placed in the abdomen of mice, where they restore the pancreatic function. Senior author Daniel Anderson, an associate professor at MIT, said in a statement that this approach "has the potential to provide [human] diabetics with a new pancreas that is protected from the immune system, which would allow them to control their blood sugar without taking drugs. That's the dream."

12. Immunotherapy is on the cutting edge of immune system research.

Over the last few years, research in the field of immunology has focused on developing cancer treatments using immunotherapy. This method engineers the patient's own normal cells to attack the cancer cells. Vance says the technique could be used for many more conditions. "I feel like that could be just the tip of the iceberg," he says. "If we can understand better what the cancer and immunotherapy is showing, maybe we can go in there and manipulate the immune responses and get good outcomes for other diseases, too."

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