10 Dubious Victorian Cures From the First Merck Manual of Diagnosis and Therapy

Wellcome Images // CC BY 4.0 (cropped)
Wellcome Images // CC BY 4.0 (cropped)

In his work Of the Epidemics, the Greek physician Hippocrates encouraged doctors to “have two special objects in view with regard to disease, namely, to do good or to do no harm.” Yet the history of medicine has been an exercise in trial and error, with remedies sometimes proving more dangerous than the disease.

Examples of such dubious and sometimes potentially deadly cures abound in the first edition of The Merck Manual of Diagnosis and Therapy, the oldest continuously published English-language medical textbook. First published by the American drug manufacturer Merck & Co in 1899, the manual’s original edition suggests remedies such as hot baths for heat exhaustion, coffee for insomnia, nitroglycerin for headaches, and opium for constipation.

“What’s most fascinating to me are drugs that have an immediate dangerous effect,” says Robert S. Porter, M.D., editor-in-chief of the manual’s 20th edition, which was published earlier this year. “Cocaine for angina? Cocaine is a vasoconstrictor that causes heart attack. Give it to someone with angina and they might die. The bulk of the book is things that simply don't work—that are useless or odd—but these ones really raise questions as to how people could recommend them.”

Here's a selection of puzzling remedies from the first edition, some of which went on to be recommended for decades.

1. ARSENIC FOR ANEMIA

A page from the Merck Manual about anemia
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Arsenic was one of the top remedies the manual recommended for anemia. Though arsenic had been known as a poison since ancient times, medicines containing small doses of the substance were long used for conditions ranging from anthrax to syphilis to anemia. By the 19th century, arsenic was being inhaled as vapors, ingested, injected, and given in enemas for a variety of ailments. In fact, so many people suffered symptoms—such as rashes, stomach distress, and headaches—from taking arsenic remedies during the Victorian era that their ailments are now sometimes referred to as “Fowler’s disease," after the popular remedy Fowler’s Solution, which contained potassium arsenite.

2. LAXATIVES FOR CHICKENPOX

A page from the Merck Manual about chickenpox
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Before chickenpox vaccinations became available in the U.S. in 1995, an average of 4 million people each year suffered through itchy outbreaks. When the Merck Manual was first published, part of the comprehensive treatment plan for an "eruptive fever"—whether it was chickenpox, smallpox, or scarlet fever—was laxatives, ideally a dose of castor oil. The idea was to purge the body of the infectious disease, but such treatment usually just compounded the misery and forced the patient to stay close to the toilet.

3. STRYCHNINE FOR CONSTIPATION

A page from the Merck Manual about constipation
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Even a tiny dose of strychnine can cause convulsions. Yet the Merck Manual, following the medical practice of the day, recommended small amounts as a treatment for acute constipation. Commonly derived from the plant Strychnos nux-vomica, strychnine was thought to improve gastric function. (Strychnine injections were also recommended for both flatulence and ulcers.) Opium and turpentine were also recommended, but patients probably derived more relief from the less dramatic manual-recommended regimens, such as eating apples and figs or drinking coffee.

4. CHLOROFORM FOR HICCUPS

A page from the Merck Manual about hiccups
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Bad case of the hiccups? Today, you might be told to hold your breath or drink water. But in 1899, your doctor might recommend inhaling chloroform. An organic compound that also a popular anesthetic in the 19th and early 20th century, chloroform eventually fell out of favor because of its potential to damage the nervous system, liver, and kidneys. Other hiccup remedies listed in the Merck manual included nitroglycerin and the slightly less toxic sugar and vinegar.

5. INHALING SMOKE FOR ASTHMA

A page from the Merck Manual about asthma
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

As counterintuitive as it seems today, the manual noted that "smoking is sometimes beneficial" for asthma, adding that “cannabis indica can be used in chronic cases.” The manual was far from alone in recommending the practice; throughout the late 19th and early 20th centuries, inhaling the fumes of tobacco and cannabis, as well as stramonium (a hallucination-inducing nightshade) and lobelia (a flowering plant known for its sedative properties) were popular treatments for asthmatics. There were even special anti-asthma cigarettes. We now know that inhaling any kind of smoke has been shown to damage and eventually reduce the number of cilia—the fine lung filaments which, when healthy, help transport mucus in the lungs—which only leads to a worsening of asthma symptoms.

6. BLOODLETTING FOR NAUSEA

A page from the Merck Manual about nausea
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Bloodletting—with leeches or other means—has been used to treat various ailments, including excessive bleeding, for thousands of years. The Ancient Greek physicians thought that it was sometimes necessary to balance blood and other bodily fluids, known as humors. The practice remained a standard treatment for many ailments, including nausea and morning sickness during pregnancy, well into the 19th century. It was thought to regulate the pulse, alleviate fever, and calm pain. While bloodletting can actually help with a few conditions, such as hemochromatosis (a genetic disorder leading to abnormal iron accumulation in the liver), doctors eventually realized that bleeding could also weaken patients and that frequent cutting could lead to infections.

As well as this traditional remedy, the manual’s first edition also recommended cocaine, the wonder drug of the day, to treat all kinds of nausea. Better and less stomach-turning effects could have been achieved with another recommended remedy: cinnamon.

7. COLD DOUCHES FOR INSOMNIA

A page from the Merck Manual about insomnia
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Alcohol, cannabis indica, and “cold douches” were effective remedies for insomnia, according to the Merck Manual. Cold douches—being blasted with cold water—might not seem sleep-inducing, yet in the late 19th and early 20th century this form of hydrotherapy was recommended as a way to improve circulation, fight infection, and treat headaches as well as insomnia. “By this means, the brain is enabled to resume a healthier mode of action, and sleep follows as a matter of course,” wrote Dr. Henry M. Lyman in his 1885 book Insomnia and Other Disorders of Sleep. Other remedies the manual recommended for insomnia included coffee, alcohol, and putting hot water bags on your feet while applying cold ones to your head.

8. BELLADONNA FOR COLIC

A page from the Merck Manual about colic
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Misguided medical notions were also applied to easing colic—the severe bouts of stomach pain often suffered by very young babies. The Merck Manual recommended ammonia, turpentine, and belladonna—a poisonous plant in the deadly nightshade family—for relief from colic spasms. Belladonna is still used modern medicines for adults (it's the main ingredient in the drops your eye doctor uses to dilate your eyes), but according to the FDA, “there is no known safe dose or toxic dose of belladonna in children.” In 2010, the FDA warned against its use in homeopathic teething tablets.

9. LEECHES FOR EARACHES

A page from the Merck Manual about leeches for earaches
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

Using leeches for an ear infection might sound disgusting at best, but there was some medical justification for the manual's recommendation. Once leeches are firmly attached to their host, they can numb pain, while peptides and proteins in their saliva prevent blood clotting, so they can help drain an infection. Modern medicine has recently taken another look at leeches: In 2004, the FDA decided the creatures met the definition of a live medical device, since their tiny jaws (and anticoagulants) keep blood flowing, which helps wounds to heal. They can also be used to break up blood clots, treat varicose veins, and improve other circulatory disorders.

10. COCAINE FOR ALCOHOLISM

A page from the Merck Manual about alcoholism
Merck's 1899 Manual of the Materia Medica, Internet Archive // Public Domain

In the 1880s, Sigmund Freud helped popularize the idea of using cocaine to treat alcoholism, calling it a “magical drug.” In its heyday, cocaine was also promoted as a cure for morphine addiction, depression, anxiety, fatigue, and migraines. It was available over the counter in tonics, powders, wines, and soft drinks. Patients likely felt energized by regular cocaine infusions, but they soon became habituated. (Freud experimented on himself for a few years until the mounting evidence of cocaine’s addictive nature proved too much to ignore; the drug was made illegal in the U.S. in 1914.) The 1899 manual also offered simpler, less dangerous—but also likely ineffective—ways to battle alcohol cravings, including slowly sucking an orange or drinking water hot ("one pint drunk as hot as possible an hour before meals will remove craving"), or cold in small sips.

Everything You Need to Know About the New DC Universe Streaming Service

Brenton Thwaites stars in DC Universe's Titans
Brenton Thwaites stars in DC Universe's Titans
Warner Bros. Television

by Natalie Zamora

Although the fates of two major DC superheroes, Superman and Batman, are kind of up in the air right now as far as for their Extended Universes, things are looking up for the franchise, as their exclusive streaming service has just launched. Here's everything you need to know about DC Universe.

THE SIGNIFICANCE

With all the different types of streaming services we have today, why is DC Universe so special, and why would someone pay for it if they can find the content elsewhere? Well, this streaming service allows all your favorite DC content to live in one space. Instead of having to search for what you want throughout the internet, you can find it all here. For the die-hard fan, this is perfect.

DC Universe offers an impressive collection of live-action and animated movies, TV shows, documentaries, and comic books. The service also offers exclusive toys you can only get by being a subscriber.

THE CONTENT

Heath Ledger stars as The Joker in 'The Dark Knight' (2008)
© TM & DC Comics/Warner Bros. Entertainment Inc.

So, what exact DC content lives on DC Universe? Well, there's a range of content from recent to old-school, such as Batman: The Animated Series, The Dark Knight, Teen Titans, and Constantine. Apart from what's on there now, the service will be debuting the live-action Titans series later this year, along with Swamp Thing and Doom Patrol in 2019. DC is also developing new series for Harley Quinn and Young Justice: Outsiders, exclusively for the service.

THE PRICE

​To get all of this exclusive DC content, it must be expensive, right? No, not really. Compared to Netflix, which is $10.99 a month, DC Universe is inexpensive, at a rate of $7.99 monthly or $74.99 annually. It is a bit pricier than Hulu, however, which is $5.99 monthly for the first year, then $7.99 monthly after. Like most streaming services, you can also try a free seven-day trial with DC Universe.

HOW TO SIGN UP

​Are you sold? If so, the sign up process is fairly simple. Head to ​DC Universe, create an account, and choose your plan, either monthly or annually. Either way, you'll get your free seven-day trial to browse around and see for yourself if it's really worth it.

10 Classic Books That Have Been Banned

iStock
iStock

From the Bible to Harry Potter, some of the world's most popular books have been challenged for reasons ranging from violence to occult overtones. In honor of National Book Lovers Day, here's a look at 10 classic books that have stirred up controversy.

1. THE CALL OF THE WILD

The Call of the Wild, Jack London's 1903 Klondike Gold Rush-set adventure, was banned in Yugoslavia and Italy for being "too radical" and was burned by the Nazis because of the author's well-known socialist leanings.

2. THE GRAPES OF WRATH

Though The Grapes of Wrath—John Steinbeck's 1939 novel about a family of tenant farmers who are forced to leave their Oklahoma home for California because of economic hardships—earned the author both the National Book Award and a Pulitzer Prize, it also drew ire across America because some believed it promoted Communist values. Kern County, California (where much of the book took place) was particular incensed by Steinbeck's portrayal of the area and its working conditions, which they considered slanderous.

3. THE LORAX

The cover of Dr. Seuss' The Lorax
Google Play

Whereas some readers look at the title character Dr. Seuss's The Lorax and see a fuzzy little guy who "speaks for the trees," others saw the 1971 children's book as a dangerous piece of political commentary, with even the author reportedly referring to it as "propaganda."

4. ULYSSES

James Joyce's 1922 novel Ulysses may be one of the most important and influential works of the early 20th century, but it was also deemed obscene for both its language and sexual content—and not just in a few provincial places. In 1921, a group known as The New York Society for the Suppression of Vice successfully managed to keep the book out of the United States, and the United States Post Office regularly burned copies of it. But in 1933, the book's publisher, Random House, took the case—United States v. One Book Called Ulysses—to court, and ended up getting the ban overturned.

5. ALL QUIET ON THE WESTERN FRONT

In 1929, Erich Maria Remarque—a German World War I veteran—wrote the novel All Quiet on the Western Front, which gives an accounting of the extreme mental and physical stress the German soldiers faced during their time in the war. Perhaps unsurprisingly, the book's realism didn't sit well with Nazi leaders, who feared the book would deter their propaganda efforts.

6. ANIMAL FARM

The cover of George Orwell's Animal Farm
Public Domain, Wikimedia Commons

The original publication of Animal Farm, George Orwell's 1945 allegorical novella, was delayed in the UK because of its anti-Stalin themes. It was confiscated in Germany by Allied troops, banned in Yugoslavia in 1946, banned in Kenya in 1991, and banned in the United Arab Emirates in 2002.

7. AS I LAY DYING

Though many people consider William Faulkner's 1930 novel As I Lay Dying a classic piece of American literature, the Graves County School District in Mayfield, Kentucky disagreed. In 1986, the school district banned the book because it questioned the existence of God.

8. LOLITA

Sure, it's well known that Vladimir Nabokov's Lolita is about a middle-aged literature professor who is obsessed with a 12-year-old girl who eventually becomes his stepdaughter. It's the kind of storyline that would raise eyebrows today, so imagine what the response was when the book was released in 1955. A number of countries—including France, England, Argentina, New Zealand, and South Africa—banned the book for being obscene. Canada did the same in 1958, though it later lifted the ban on what is now considered a classic piece of literature—unreliable narrator and all.

9. THE CATCHER IN THE RYE

Cover of The Catcher in the Rye

Reading J.D. Salinger's The Catcher in the Rye has practically become a rite of passage for teenagers, but back when it was published in 1951, it wasn't always easy for a kid to get his or her hands on it. According to TIME, "Within two weeks of its 1951 release, J.D. Salinger’s novel rocketed to No. 1 on the New York Times best-seller list. Ever since, the book—which explores three days in the life of a troubled 16-year-old boy—has been a 'favorite of censors since its publication,' according to the American Library Association."

10. THE GIVER

The newest book on this list, Lois Lowry's 1993 novel The Giverabout a dystopia masquerading as a utopiawas banned in several U.S. states, including California and Kentucky, for addressing issues such as euthanasia.

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