How Much You Need to Exercise for Better Mental Health, According to Science

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With the recent controversy over the health benefits of fish oil and other wellness strategies, it can be reassuring to know that one thing remains constant: Exercise is good for your body. Any movement, even walking, brings about a host of cardiovascular effects that can help you live longer, feel better, and not run out of breath when chasing children or small animals.

The question of how much exercise is best, though, is open to debate. The answer often depends on your goals. For heart health, sessions four to five times weekly might be ideal. For mental health? As The Independent reports, scientists believe there’s a pretty specific prescription: Exercising for 45 minutes three to five times a week.

The data comes from a new and expansive observational study published in The Lancet Psychiatry and conducted by researchers at Yale and the University of Oxford. The study examined 1.2 million subjects who filled out the Behavioral Risk Factor Surveillance Survey at two-year intervals between 2011 and 2015. Subjects who didn’t exercise at all had an average of three-and-a-half days per month when they felt mentally unwell—stressed, depressed, or otherwise burdened by emotional problems—while those who exercised regularly reported an average of just two days.

The study found that a regimen of three to five 45-minute sessions a week was optimal for reducing the reported instances of feeling stressed or depressed. Exercising for longer periods—some subjects reported exceeding 90 minutes in the gym—was associated with a drop-off in mental health benefits. Subjects who spent three hours at a time exercising actually reported an increase in depressive symptoms, a possible consequence of having obsessive personality traits that could influence their overall psychological state.

Researchers also found that the kind of exercise undertaken made a difference. While all varieties helped, people who participated in team sports promoting social interaction and gym classes like cycling or aerobics described greater self-satisfaction with mental health.

Because the study involved self-reported outcomes and exercise wasn't monitored, it's possible that the participants could have misinterpreted the volume of exercise performed. The scope of the study, however, makes a convincing case for a popular notion: If exercise were a pill, doctors everywhere would be prescribing it.

[h/t The Independent]

FDA Recalls Thyroid Medications Due to Contamination Risk

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Hypothyroid medications manufactured by Westminster Pharmaceuticals have been recalled after it was discovered that one of the company’s Chinese suppliers failed to meet U.S. Food and Drug Administration (FDA) standards, CNN reports.

The oral tablets contain levothyroxine (LT4) and liothyronine (LT3), which are both synthetic hormones used to treat thyroid conditions.

The medicine was recalled as a precaution after it was discovered during a 2017 FDA inspection that the Chinese supplier in question, Sichuan Friendly Pharmaceutical Co., was not practicing good manufacturing practices.

However, patients with serious thyroid conditions shouldn’t throw out their pills just yet. No adverse effects from the medication have been reported, and the risk of not taking the medication outweighs the risk of taking a recalled pill.

According to the FDA, “Because these products may be used in the treatment of serious medical conditions, patients taking the recalled medicines should continue taking their medicine until they have a replacement product.”

For more information on the specific lots and products in question, visit the FDA’s website.

[h/t CNN]

A 'Zombie Gene' Might Be the Reason Elephants Rarely Get Cancer

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When it comes to cancer rates in the animal kingdom, elephants are an anomaly. As Popular Science notes, cancer should be more common among larger species, but with elephants, that simply isn’t the case. Only about 5 percent of elephants die from cancer, compared to 11 to 25 percent of humans.

In a new study, published in Cell Reports, University of Chicago researchers found what’s believed to be the genetic source of elephants’ cancer immunity. Elephants, like all mammals, have a gene called LIF that is known to suppress tumors. Humans have one copy of this gene, but elephants have 10 copies, which have developed over 80 million years of evolution. However, only one of those copies, called LIF6, is functional in elephants.

The other LIF copies are essentially dead because they lack a specific piece of DNA to make them function. At some point during the evolutionary process, the LIF6 gene copy turned back on, but scientists don’t know why or when this occurred. This “zombie gene” helps kill mutated cells, in true Night of the Living Dead fashion.

“This reanimation of LIF6 occurred perhaps over 59 million years,” Joshua Schiffman, who studies cancer in elephants but was not involved in the study, told Popular Science. “That’s an amazingly long period of time for nature to modify and perfect an anticancer mechanism.”

Scientists aren’t yet sure how this could be applied to cancer research in humans, but they say it’s a promising start and a creative approach to the problem. While these findings are still fresh and need to be duplicated, it raises the possibility of creating a drug that mimics the function of LIF6.

[h/t Popular Science]

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