11 Insightful Facts About Eyes

iStock.com/Paffy69
iStock.com/Paffy69

There are a lot of myths and misconceptions about the eyes. No, sitting too close to the TV won't damage your vision, and reading in dim light won’t hurt either. It’s understandable that various parts of the eye are so little understood, though. Each eye has more than a million optic nerve cells and over 106 million photoreceptor cells, making it one of the most complex organs we have. Here are a few more things you should know about your “windows to the soul.”

1. Newborn babies see the world in black and white—and red.

“It is a myth that babies see in black and white,” Anna Franklin, leader of the University of Sussex's Baby Lab, told The Guardian. While newborns do see black, white, and shades of gray, they can also detect red objects against a gray backdrop, Franklin says. The reason why they can’t see more colors is because the cones in their eyes—the photoreceptor cells responsible for picking up colors—are too weak to detect them. Those cells quickly get stronger, though. After about two months, babies can distinguish between red and green, and a few weeks later they can tell the difference between blue and yellow.

2. Your eyeballs grow as you age.

Another common misconception is that your eyes remain the same size from birth to adulthood. As a newborn, your eyes measure about three-fifths of an inch from front to back, compared to a little under an inch in adults. Your eyes actually grow a great deal in the first two years of life, and another growth spurt occurs when you go through puberty. The confusion likely stems from the fact that your eyes as a 6-month-old infant are two-thirds the size they will be when you’re an adult.

3. The length of your eye partly determines how well you'll be able to see.

If your eyeball is too long or too short, you might end up having problems with your vision. Nearsighted people have eyes that are longer than average, while farsighted people have eyes that come up a little short. If you were to magically add or remove a millimeter of length from your eye, it would completely change your prescription. Aside from eye length, the shape of your cornea (the outer part of the eye where contact lenses are placed) and lens (the part of the eye located behind the iris and pupil) are other key factors that determine the quality of your vision. That's because both of these parts work together to refract light.

4. Contact lenses can't really get lost behind your eye.

Although it may feel like a dislodged contact lens is stuck behind your eye, that isn’t exactly what’s happening. The thin membrane covering the white part of your eye and the underside of your eyelid—called the conjunctiva—forms a pouch and prevents objects from getting behind your eyeball. If a contact lens gets shifted out of place to the point where you can no longer see it, it’s just stuck underneath your upper eyelid, which isn’t nearly as scary.

5. Blue-eyed people share a common ancestor.

Originally, everyone in the world had brown eyes. It wasn’t until around 6000 to 10,000 years ago that the first blue-eyed person was born as a result of a genetic mutation, according to a 2008 study. That mutation of the OCA2 gene essentially “turned off the ability to produce brown eyes” and diluted the color to blue, Professor Hans Eiberg of the University of Copenhagen said in a statement.

6. Parts of the eye can get sunburned.

There’s a good reason you should wear sunglasses when it’s bright outside. Too much exposure to UV rays can damage the surface of the cornea and conjunctiva, causing a condition akin to sunburn called photokeratitis. Symptoms include pain, red or swollen eyes, the sensation of a foreign body in the eyes, blurred vision, headaches, and seeing halos around lights. While the discomfort is temporary and tends to go away within 48 hours, longer exposure to UV rays can have a long-term effect on your vision and lead to macular degeneration (deterioration of the retina, which is often age-related) and cataracts (clouding of the eye's lens, which reduces the amount of light coming in).

7. Your eye muscles are the fastest muscle in your body.

Extraocular muscles are what let you look around in all directions. You have six of these muscles in each eye, and many of the motions they make are involuntary. This lets you flick your eyes to one side and notice something in your peripheral vision without consciously looking in that direction. When both of your eyes move in the same direction, the movement is called a saccade, which comes from the French word for “jerk” (the verb, not the person). These jerky movements are extremely rapid, lasting about 50 to 60 milliseconds per saccade, according to Dr. Reza Shadmehr, professor of biomedical engineering and neuroscience at Johns Hopkins University. “Saccadic eye movements are the fastest voluntary movements that we can make. The eyes move at around 500 degrees per second or more,” Shadmehr tells Mental Floss.

8. Your eye movements might give away your next move.

Shadmehr and other researchers conducted an experiment in 2015 to test the relationship between saccades and decision-making. Participants were placed in front of a computer and asked to choose between two options that appeared on the screen: an immediate reward and a delayed reward. For instance, one option might be “get $10 today,” while the other might be “wait 30 days and get $30.” Their eye movements were tracked the entire time, and researchers discovered that these movements gave away the choice they were about to make before they made it. At the last minute, their eyes would move at a faster velocity towards the option that they preferred.

“What’s interesting is that as the saccades are being made, the velocity of the eyes starts out being equal between these two stimuli, but then right before you decide ‘I like A better than B,' the saccade that you make toward A has a higher velocity than the one you make toward B,” Shadmehr explains. “The idea is that the way you’re evaluating things is reflected in the way you move toward them.”

In another experiment, Shadmehr found a correlation between faster eye movements and impatient and impulsive behaviors. Similarly, other studies have shown that our eye movements are linked to moral decisions and even our political temperament.

9. You can tell some animals' place in the food chain by looking at a part of their eye.

In 2015, vision scientist Martin Banks and his colleagues looked at the eyes of 214 species in an attempt to answer the question, “Why do animal eyes have pupils of different shapes?” By the end of their study, they noticed a few patterns. Predatory animals like big cats and snakes tend to have pupils in the shape of vertical slits. This particular shape gives them the advantage of being able to accurately judge the distance separating them and their prey, so they'll know exactly how far they have to pounce. On the other hand, horizontal pupils are more common in goats, deer, cattle, and other herbivores. This shape improves an animal’s panoramic vision, which helps them look out for predators.

10. An eye condition may have been partly responsible for Leonardo da Vinci's artistic genius.

Visual neuroscientist Christopher Tyler argued in a recent paper that the master artist behind Mona Lisa had strabismus, a disorder where the eyes are misaligned. Essentially, one of his eyes turned outwards, and he was able to use both of his eyes separately (monocular as opposed to binocular vision). Tyler believes this actually aided his art by improving his ability to render three-dimensional images on a flat canvas. “The condition is rather convenient for a painter, since viewing the world with one eye allows direct comparison with the flat image being drawn or painted,” Tyler said. We’ll never know for sure whether or not this was true for Leonardo, but it’s an intriguing theory.

11. SURGEONS HOPE TO BE PERFORMING WHOLE EYE TRANSPLANTS BY 2026. 

Currently, only cornea transplants to improve vision are possible, but a team of Pittsburgh-based transplant surgeons said in 2016 that they hoped to be performing whole eye transplants in humans within the next decade. Transferring an eye from a deceased donor to a recipient certainly won’t be easy, though. A complicated network of muscles, blood vessels, and nerves connects the eyes to the brain via the optic nerve. However, further studies into the optic nerve and recent advances in immunosuppressive drugs and surgical techniques have brought them several steps closer to achieving this goal. If successful, the surgery could restore vision to people who have suffered severe eye injuries. Their research is backed by the Department of Defense, which is concerned about the number of soldiers who sustain eye injuries in combat.

‘Water’ in Kansas City Woman’s Ear Turned Out to Be a Venomous Brown Recluse Spider

N-sky/iStock via Getty Images
N-sky/iStock via Getty Images

Susie Torres, a resident of Kansas City, Missouri, woke up on Tuesday morning with the distinct feeling that water was lodged in her left ear. She likened it to the swooshing sensation that can often happen after swimming, WDAF-TV reports.

Instead of waiting for the problem to resolve itself, Torres went to the doctor—a decision that might have saved her from some serious pain. The medical assistant was the first to realize something was alarmingly amiss, and immediately called for backup.

“She ran out and said ‘I’m going to get a couple more people,’” Torres told 41 Action News. “She then said, ‘I think you have an insect in there.’” For many people, the thought of having any live insect stuck in an ear would be enough to cue a small- or large-scale freak-out, but Torres stayed calm.

The doctors “had a few tools and worked their magic and got it out,” Torres said. The “it” in question turned out to be a spider—and not just any harmless house spider (which you shouldn’t kill, by the way). It was a venomous brown recluse spider.

“Gross,” Torres told WDAF-TV. “Why, where, what, and how.”

Miraculously, the spider didn’t bite Torres. If it had, she would’ve ended up visiting the doctor with more than general ear discomfort: Brown recluse bites can cause pain, burning, fever, nausea, and purple or blue discoloration of the surrounding skin, according to Healthline.

Torres may have remained admirably level-headed throughout the ordeal, but that doesn’t mean she’s taking it lightly. “I went and put some cotton balls in my ears last night,” she told WDAF-TV. “I’m shaking off my clothes, and I don’t put my purse on the floor. I’m a little more cautious.”

Is this the first time an insect has posted up in the ear of an unsuspecting, innocent human? Absolutely not—here are six more horror stories, featuring a cockroach, a bed bug, and more.

[h/t WDAF-TV]

12 Fantastic Facts About the Immune System

monkeybusinessimages/iStock via Getty Images
monkeybusinessimages/iStock via Getty Images

If it weren't for our immune system, none of us would live very long. Not only does the immune system protect us from external pathogens like viruses, bacteria, and parasites, but it also battles cells that have mutated due to illnesses, like cancer, within the body. Here are 12 fascinating facts about the immune system.

1. The immune system saves lives.

The immune system is a complex network of tissues and organs that spreads throughout the entire body. In a nutshell, it works like this: A series of "sensors" within the system detects an intruding pathogen, like bacteria or a virus. Then the sensors signal other parts of the system to kill the pathogen and eliminate the infection.

"The immune system is being bombarded by all sorts of microbes all the time," Russell Vance, professor of immunology at University of California, Berkeley and an investigator for the Howard Hughes Medical Institute, tells Mental Floss. "Yet, even though we're not aware of it, it's saving our lives every day, and doing a remarkably good job of it."

2. Before scientists understood the immune system, illness was chalked up to unbalanced humors.

Long before physicians realized how invisible pathogens interacted with the body's system for fighting them off, doctors diagnosed all ills of the body and the mind according to the balance of "four humors": melancholic, phlegmatic, choleric, or sanguine. These criteria, devised by the Greek philosopher Hippocrates, were divided between the four elements, which were linked to bodily fluids (a.k.a. humors): earth (black bile), air (blood), water (phlegm) and fire (yellow bile), which also carried properties of cold, hot, moist, or dry. Through a combination of guesswork and observation, physicians would diagnose patients' humors and prescribe treatment that most likely did little to support the immune system's ability to resist infection.

3. Two men who unraveled the immune system's functions were bitter rivals.

Two scientists who discovered key functions of the immune system, Louis Pasteur and Robert Koch, should have been able to see their work as complementary, but they wound up rivals. Pasteur, a French microbiologist, was famous for his experiments demonstrating the mechanism of vaccines using weakened versions of the microbes. Koch, a German physician, established four essential conditions under which pathogenic bacteria can infect hosts, and used them to identify the Mycobacterium tuberculosis bacterium that causes tuberculosis. Though both helped establish the germ theory of disease—one of the foundations of modern medicine today—Pasteur and Koch's feud may have been aggravated by nationalism, a language barrier, criticisms of each other's work, and possibly a hint of jealousy.

4. Specialized blood cells are the immune system's greatest weapon.

The most powerful weapons in your immune system's arsenal are white blood cells, divided into two main types: lymphocytes, which create antigens for specific pathogens and kill them or escort them out of the body; and phagocytes, which ingest harmful bacteria. White blood cells not only attack foreign pathogens, but recognize these interlopers the next time they meet them and respond more quickly. Many of these immune cells are produced in your bone marrow but also in the spleen, lymph nodes, and thymus, and are stored in some of these tissues and other areas of the body. In the lymph nodes, which are located throughout your body but most noticeably in your armpits, throat, and groin, lymphatic fluid containing white blood cells flows through vein-like tubules to escort foreign invaders out.

5. The spleen helps your immune system work.

Though you can live without the spleen, an organ that lies between stomach and diaphragm, it's better to hang onto it for your immune function. According to Adriana Medina, a doctor who specializes in hematology and oncology at the Alvin and Lois Lapidus Cancer Institute at Sinai Hospital in Baltimore, your spleen is "one big lymph node" that makes new white blood cells and cleans out old blood cells from the body.

It's also a place where immune cells congregate. "Because the immune cells are spread out through the body," Vance says, "eventually they need to communicate with each other." They do so in both the spleen and lymph nodes.

6. You have immune cells in all of your tissues.

While immune cells may congregate more in lymph nodes than elsewhere, "every tissue in your body has immune cells stationed in it or circulating through it, constantly roving for signs of attack," Vance explains. These cells also circulate through the blood. The reason for their widespread presence is that there are thousands of different pathogens that might infect us, from bacteria to viruses to parasites. "To eliminate each of those different kinds of threats requires specialized detectors," he says.

7. How friendly you're feeling could be linked to your immune system.

From an evolutionary perspective, humans' high sociability may have less to do with our bigger brains, and more to do with our immune system's exposure to a greater number of bacteria and other pathogens.

Researchers at the University of Virginia School of Medicine have theorized that interferon gamma (IG), a substance that helps the immune system fight invaders, was linked to social behavior, which is one of the ways we become exposed to pathogens.

In mice, they found IG acted as a kind of brake to the brain's prefrontal cortex, essentially stopping aberrant hyperactivity that can cause negative changes in social behavior. When they blocked the IG molecule, the mice's prefrontal cortexes became hyperactive, resulting in less sociability. When they restored the function, the mice's brains returned to normal, as did their social behavior.

8. Your immune system might recruit unlikely organs, like the appendix, into service.

The appendix gets a bad rap as a vestigial organ that does nothing but occasionally go septic and create a need for immediate surgery. But the appendix may help keep your gut in good shape. According to Gabrielle Belz, professor of molecular immunology at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, research by Duke University's Randal Bollinger and Bill Parker suggests the appendix houses symbiotic bacteria that are important for overall gut health—especially after infections wipe out the gut's good microbes. Special immune cells known as innate lymphoid cells (ILCs) in the appendix may help to repopulate the gut with healthy bacteria and put the gut back on track to recovery.

9. Gut bacteria has been shown to boost immune systems in mice.

Researchers at the University of Chicago noticed that one group of mice in their lab had a stronger response to a cancer treatment than other mice. They eventually traced the reason to a strain of bacteria—Bifidobacterium—in the mice's guts that boosted the animals' immune system to such a degree they could compare it to anti-cancer drugs called checkpoint inhibitors, which keep the immune system from overreacting.

To test their theory, they transferred fecal matter from the robust mice to the stomachs of less immune-strengthened mice, with positive results: The treated mice mounted stronger immune responses and tumor growth slowed. When they compared the bacterial transfer effects with the effects of a checkpoint inhibitor drug, they found that the bacteria treatment was just as effective. The researchers believe that, with further study, the same effect could be seen in human cancer patients.

10. Scientists are trying to harness the immune system's "Pac-Man" cells to treat cancer.

Aggressive pediatric tumors are difficult to treat due to the toxicity of chemotherapy, but some researchers are hoping to develop effective treatments without the harmful side effects. Stanford researchers designed a study around a recently discovered molecule known as CD47, a protein expressed on the surface of all cells, and how it interacts with macrophages, white blood cells that kill abnormal cells. "Think of the macrophages as the Pac-Man of the immune system," Samuel Cheshier, lead study author and assistant professor of neurosurgery at Stanford Medicine, tells Mental Floss.

CD47 sends the immune system's macrophages a "don't eat me" signal. Cancer cells fool the immune system into not destroying them by secreting high amounts of CD47. When Cheshier and his team blocked the CD47 signals on cancer cells, the macrophages could identify the cancer cells and eat them, without toxic side effects to healthy cells. The treatment successfully shrank all five of the common pediatric tumors, without the nasty side effects of chemotherapy.

11. A new therapy for type 1 diabetes tricks the immune system.

In those with type 1 diabetes, the body attacks its own pancreatic cells, interrupting its normal ability to produce insulin in response to glucose. In a 2016 paper, researchers at MIT, in collaboration with Boston's Children's Hospital, successfully designed a new material that allows them to encapsulate and transplant healthy pancreatic "islet" cells into diabetic mice without triggering an immune response. Made from seaweed, the substance is benign enough that the body doesn't react to it, and porous enough to allow the islet cells to be placed in the abdomen of mice, where they restore the pancreatic function. Senior author Daniel Anderson, an associate professor at MIT, said in a statement that this approach "has the potential to provide [human] diabetics with a new pancreas that is protected from the immune system, which would allow them to control their blood sugar without taking drugs. That's the dream."

12. Immunotherapy is on the cutting edge of immune system research.

Over the last few years, research in the field of immunology has focused on developing cancer treatments using immunotherapy. This method engineers the patient's own normal cells to attack the cancer cells. Vance says the technique could be used for many more conditions. "I feel like that could be just the tip of the iceberg," he says. "If we can understand better what the cancer and immunotherapy is showing, maybe we can go in there and manipulate the immune responses and get good outcomes for other diseases, too."

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