14 Facts About Celiac Disease

iStock.com/fcafotodigital
iStock.com/fcafotodigital

Going gluten-free may be a modern diet trend, but people have been suffering from celiac disease—a chronic condition characterized by gluten intolerance—for centuries. Patients with celiac are ill-equipped to digest products made from certain grains containing gluten; wheat is the most common. In the short-term this can cause gastrointestinal distress, and in the long-term it can foster symptoms associated with early death.

Celiac diagnoses are more common than ever, which also means awareness of how to live with the condition is at an all-time high. Here are some things you might not know about celiac disease symptoms and treatments.

1. Celiac an autoimmune disease.

The bodies of people with celiac have a hostile reaction to gluten. When the protein moves through the digestive tract, the immune system responds by attacking the small intestine, causing inflammation that damages the lining of the organ. As this continues over time, the small intestine has trouble absorbing nutrients from other foods, which can lead to additional complications like anemia and osteoporosis.

2. You can get celiac disease from your parents.

Nearly all cases of celiac disease arise from certain variants of the genes HLA-DQA1 and HLA-DQB1. These genes help produce proteins in the body that allow the immune system to identify potentially dangerous foreign substances. Normally the immune system wouldn't label gliadin, a segment of the gluten protein, a threat, but due to mutations in these genes, the bodies of people with celiac treat gliadin as a hostile invader.

Because it's a genetic disorder, people with a first-degree relative (a sibling, parent, or child) with celiac have a 4 to 15 percent chance of having it themselves. And while almost all patients with celiac have these specific HLA-DQA1 and HLA-DQB1 variations, not everyone with the mutations will develop celiac. About 30 percent of the population has these gene variants, and only 3 percent of that group goes on to develop celiac disease.

3. Makeup might contribute to celiac disease symptoms.

People with celiac disease can’t properly process gluten, the protein naturally found in the grains like wheat, rye, and barley. Patients have to follow strict dietary guidelines and avoid most bread, pasta, and cereal, in order to manage their symptoms. But gluten isn’t limited to food products: It can also be found in some cosmetics. While makeup containing gluten causes no issues for many people with celiac, it can provoke rashes in others or lead to more problems if ingested. For those folks, gluten-free makeup is an option.

4. The name comes from 1st-century Greece.

A 1st-century Greek physician named Aretaeus of Cappadocia may have been the first person to describe celiac disease symptoms in writing [PDF]. He named it koiliakos after the Greek word koelia for abdomen, and he referred to people with the condition as coeliacs. In his description he wrote, “If the stomach be irretentive of the food and if it pass through undigested and crude, and nothing ascends into the body, we call such persons coeliacs.”

5. There are nearly 300 celiac disease symptoms.

Celiac disease may start in the gut, but it can be felt throughout the whole body. In children, the condition usually manifests as bloating, diarrhea, and abdominal discomfort, but as patients get older they start to experience more “non-classical” symptoms like anemia, arthritis, and fatigue. There are at least 281 symptoms associated with celiac disease, many of which overlap with other conditions and make celiac hard to diagnose. Other common symptoms of the disease include tooth discoloration, anxiety and depression, loss of fertility, and liver disorders. Celiac patients also have a greater chance of developing an additional autoimmune disorder, with the risk increasing the later in life the initial condition is diagnosed.

6. Some patients show no symptoms at all.

It’s not uncommon for celiac disease to be wrecking a patient’s digestive tract while showing no apparent symptoms. This form of the condition, sometimes called asymptomatic or “silent celiac disease,” likely contributes to part of the large number of people with celiac who are undiagnosed. People who are at high risk for the disease (the children of celiac sufferers, for example), or who have related conditions like type 1 diabetes and Down syndrome (both conditions that put patients at a greater risk for developing new autoimmune diseases) are encouraged to get tested for it even if they aren’t showing any signs.

7. It’s not the same as wheat sensitivity.

Celiac is often confused with wheat sensitivity, a separate condition that shares many symptoms with celiac, including gastrointestinal issues, depression, and fatigue. It’s often called gluten sensitivity or gluten intolerance, but because doctors still aren’t sure if gluten is the cause, many refer to it as non-celiac wheat sensitivity. There’s no test for it, but patients are often treated with the same gluten-free diet that’s prescribed to celiac patients.

8. It's not a wheat allergy either.

Celiac disease is often associated with wheat because it's one of the more common products containing gluten. While it's true that people with celiac can't eat wheat, the condition isn't a wheat allergy. Rather than reacting to the wheat, patients react to a specific protein that's found in the grain as well as others.

9. It can develop at any age.

Just because you don’t have celiac now doesn’t mean you’re in the clear for life: The disease can develop at any age, even in people who have tested negative for it previously. There are, however, two stages of life when symptoms are most likely to appear: early childhood (8 to 12 months) and middle adulthood (ages 40 to 60). People already genetically predisposed to celiac become more susceptible to it when the composition of their intestinal bacteria changes as they get older, either as a result of infection, surgery, antibiotics, or stress.

10. Not all grains are off-limits.

A gluten-free diet isn’t necessarily a grain-free diet. While it’s true that the popular grains wheat, barley, and rye contain gluten, there are plenty of grains and seeds that don’t and are safe for people with celiac to eat. These include quinoa, millet, amaranth, buckwheat, sorghum, and rice. Oats are also naturally gluten-free, but they're often contaminated with gluten during processing, so consumers with celiac should be cautious when buying them.

11. Celiac disease can be detected with a blood test.

Screenings for celiac disease used to be an involved process, with doctors monitoring patients’ reactions to their gluten-free diet over time. Today all it takes is a simple test to determine whether someone has celiac. People with the condition will have anti-tissue transglutaminase antibodies in their bloodstream. If a blood test confirms the presence of these proteins in a patient, doctors will then take a biopsy of their intestine to confirm the root cause.

12. The gluten-free diet doesn’t work for all patients.

Avoiding gluten is the most effective way to manage celiac disease, but the treatment doesn’t work 100 percent of the time. In up to a fifth of patients, the damaged intestinal lining does not recover even a year after switching to a gluten-free diet. Most cases of non-responsive celiac disease can be explained by people not following the diet closely enough, or by having other conditions like irritable bowel syndrome, lactose intolerance, or small intestine bacterial overgrowth that impede recovery. Just a small fraction of celiac disease sufferers don’t respond to a strict gluten-free diet and have no related conditions. These patients are usually prescribed steroids and immunosuppressants as alternative treatments.

13. If you don’t have celiac, gluten probably won’t hurt you.

The gluten-free diet trend has exploded in popularity in recent years, and most people who follow it have no medical reason to do so. Going gluten-free has been purported to do everything from help you lose weight to treat autism—but according to doctors, there’s no science behind these claims. Avoiding gluten may help some people feel better and more energetic because it forces them to cut heavily processed junk foods out of their diet. In such cases it’s the sugar and carbs that are making people feel sluggish—not the gluten protein. If you don’t have celiac or a gluten sensitivity, most experts recommend saving yourself the trouble by eating healthier in general rather than abstaining from gluten.

14. The numbers are growing.

A 2009 study found that four times as many people have celiac today than in the 1950s, and the spike can’t be explained by increased awareness alone. Researchers tested blood collected at the Warren Air Force Base between 1948 and 1954 and compared them to fresh samples from candidates living in one Minnesota county. The results supported the theory that celiac has become more prevalent in the last half-century. While experts aren’t exactly sure why the condition is more common today, it may have something to do with changes in how wheat is handled or the spread of gluten into medications and processed foods.

7 Ships That Disappeared Without a Trace

iStock/stock_colors
iStock/stock_colors

There’s something ghoulishly fascinating about a mysterious disappearance, and our vast oceans offer seemingly endless space in which to vanish. The true fate of many of these ships will never be known, but speculation suggests that storms, piracy, mutiny, accidental bombing, and even the attack of a giant squid could be responsible for their vanishings. Below are seven ships that have disappeared without leaving a trace.

1. The Patriot // The disappearance of Theodosia Burr Alston

Theodosia Burr Alston (1783–1813) was the daughter of American politician and third vice president of the United States Aaron Burr. Theodosia had a privileged upbringing and a good education, and in 1801 she married wealthy landowner Joseph Alston, who went on to become governor of South Carolina. Sadly, in 1812, Theodosia lost her only son to a fever and she became sick with grief. Desperate for a change of scene, on New Year’s Eve 1812 she boarded the schooner Patriot in South Carolina to visit her father in New York. It is known that the ship left dock and sailed north, but what happened after that is a mystery. It never arrived in New York, and no trace of the ship or crew was ever found. A number of theories and legends have sprung up around the fate of Theodosia—some claim the ship was attacked by pirates and that she was forced to walk the plank, while others suggest that the Patriot got caught up in the War of 1812 and was sunk accidentally by an enemy ship. Perhaps most fanciful of all is the story put forward by a Karankawa Indian chief, who claimed that he rescued a woman who had washed up on shore after a shipwreck, and that before she died she gifted him her locket—with the name Theodosia inscribed upon it. Whatever the story, it is likely that after more than 200 years we shall never know the real fate of the Patriot and Theodosia Burr Alston.

2. The Merchant Royal // One of the richest shipwrecks never found

The Merchant Royal was tasked with taking treasures from the New World to Spain under the command of one Captain John Limbrey. In 1641 the ship was loaded with 100,000 pounds of gold, 400 bars of Mexican silver and a huge amount of precious jewels. As the ship entered the English waters, the weather turned bad, but unfortunately the pumps on board the ship broke and it began to take on water. Its sister ship, the Dover Merchant, with whom it had been sailing in tandem, came to the rescue of the captain and crew but were unable to take any of the cargo. The ship disappeared beneath the waves, somewhere off the coast of Land’s End.

Of course, with such valuable cargo, countless people have attempted to find the wreck, which has become known as the “Eldorado of the seas.” In 2007, it was thought that Odyssey Marine Exploration may have found the wreck after it salvaged 500,000 pieces of gold and silver from a site off the southwestern tip of Great Britain. This was later identified as treasure from a Spanish vessel—meaning that the unimagined riches of the Merchant Royal still await discovery.

3. USS Cyclops // Victim of the Bermuda Triangle?

The USS Cyclops was a huge steel-hulled fuel ship, tasked with carrying coal and other useful supplies for the U.S. Navy in the 1910s. On her final journey, the Cyclops set sail from Rio de Janeiro, with a full load of 10,800 tons of manganese ore and over 300 people on board. On March 4, 1918 the ship was spotted for the last time as it left Barbados and sailed into what we now sometimes call the Bermuda Triangle. The ship seemingly disappeared without a trace, and the case has been seen as especially mysterious since no distress call was made and no bad weather was reported in the region. Theories began to surface (some more imaginative than others) that the ship had been sunk by the Germans, attacked by a giant squid or octopus, or been victim of a violent mutiny. A huge search for the Cyclops was launched with a number of boats and planes scouring the area for debris or survivors, but nothing of the enormous ship was ever seen again.

4. The Witchcraft // The “unsinkable” luxury yacht

On December 22, 1967, experienced yachtsman Dan Burack and his friend, Father Patrick Horgan, set sail in the 23-foot luxury yacht Witchcraft to see the holiday lights off the coast of Miami. Unfortunately after just one mile the pair experienced difficulty when it seemed as if the yacht had hit something. Burack calmly called the Miami Coast Guard to report the trouble and request assistance. The official who took the call later commented that Burack seemed unconcerned—perhaps because the yacht was fitted with a special flotation device that was supposed to make the vessel unsinkable. The Coast Guard arrived at the scene just 19 minutes after the call, and were surprised to find no trace of the large yacht, no debris, and no sign of Burack or Horgan. Over the next six days, hundreds of square miles of ocean were searched, but nothing was ever found, and the Witchcraft has been chalked up as another vessel mysteriously lost to the Bermuda Triangle.

5. Andrea Gail // Lost in the “perfect storm”

The Andrea Gail was a 72-foot-long-liner boat that fished in the North Atlantic for swordfish. In September 1991 the ship, along with several other fishing vessels, set sail from Gloucester, Massachusetts for the last fishing session of the season. By October, the Andrea Gail and its six-man crew was out off the coast of Newfoundland when the confluence of terrible weather fronts conspired to create what has been dubbed “the perfect storm.” The massively powerful winds were whipping waves as high as 100 feet, and any ship caught in their path faced being sucked into the wave and flipped over repeatedly. The devastating storm battered the coast of New England and Canada, and after the worst of it had passed and the Andrea Gail had failed to return to port, a number of rescue missions set out to find the ship—but nothing was ever found. The story of the storm and the imagined fate of the Andrea Gail and her crew was later told in the book The Perfect Storm by Sebastian Junger, as well as a Hollywood movie of the same name.

6. The USS Porpoise // Caught in a typhoon

USS Porpoise was a brig involved in 19th century exploration and surveying missions, taking part in a voyage in 1838 that confirmed the existence of Antarctica and later circumnavigating the globe. In 1854 the ship set sail from Hong Kong carrying 69 men in order to carry out a survey of the South Sea Islands. Somewhere between China and Taiwan, the ship sailed into dense fog and was separated from its partner ship, the USS Vincennes, and never seen again. Many ships searched for the ill-fated brig for over a year, but no sign was ever found, and it's thought to have been wrecked in a typhoon with all hands lost.

7. HMS Sappho // Presumed Wrecked Off Australian Coast

Over the course of a 20-year career, the British Navy ship HMS Sappho worked to suppress the slave trade off the coast of West Africa, intercepting a number of ships loaded with slaves and freeing hundreds of people. In 1857, after wrongly chasing down and boarding an American ship—an event that caused something of a diplomatic crisis between America and Great Britain—the ship was ordered to set sail to Australia. The Sappho reached Cape Town without incident, and from there headed toward the Bass Strait, where it was last spotted by a passing brig on February 18, 1878. Bad weather was reported in the area, and it has been assumed that high winds caused the ship to founder and sink. No sign of the 147 crewmembers was ever found, but rumors abounded that the captain, Fairfax Moresby, had somehow escaped the wreck and made it to an island off Australia, where he was said to have lost his mind.

Bonus: Baychimo // Arctic ghost ship

The SS Baychimo somewhere in Canada
The SS Baychimo somewhere in Canada
Mysterious Disappearances, Wikimedia // Public Domain

The SS Baychimo started life as a German trading vessel before being given to Great Britain after World War I as part of reparations. The Baychimo came under the ownership of the Hudson Bay Company, and made many voyages across the Atlantic from Scotland to Canada to trade with local Inuit tribes. In 1931, while journeying to Vancouver with a cargo of furs, the Baychimo fell victim to an early winter, as ice floes surrounded the ship and locked it in an icy embrace. The crew escaped the stricken vessel and fled across the ice floes to safety, but some returned a few days later to try to rescue the ship and its valuable cargo.

After over a month of braving the treacherous weather in a flimsy camp, a huge blizzard hit and the remaining crew lost sight of the ship. Once the storm had cleared, the watching crew were surprised to find the Baychimo had disappeared. They assumed it had sunk without trace. A week later the ship was spotted by an Inuit hunter and the crew raced back on board to gather as much of the cargo as possible. The captain decided the ship was too badly damaged to be seaworthy and so abandoned it, thinking it would soon break apart. How wrong he was. Over the years, the Baychimo was sighted a number of times, sometimes caught fast in ice, other times floating ghost-like through the Arctic waters. The last confirmed sighting was in 1969—an astonishing 37 years after it had been abandoned to its fate.

This list was first published in 2016 and republished in 2019.

5 Terrifyingly Huge Spiders

iStock/clauselsted
iStock/clauselsted

This week, woman in Tasmania came upon a massive huntsman spider devouring a pygmy possum at a lodge in the island's Mount Field National Park. The alarmingly huge arachnid was at least the size of a grown man's hand, and it's not the only giant spider out there. The enormous spiders below can’t be dispatched by a shoe or a rolled-up newspaper. They're sure to give you nightmares—even if you're not an arachnophobe.

1. Poecilotheria rajaei

Poecilotheria rajaei, a huge spider native to Sri Lanka
Ranil Nanayakkara/British Tarantula Society, Wikimedia Commons // CC BY 3.0

This species of tarantula, discovered in northern Sri Lanka in 2013, has a leg span of 8 inches. That's roughly the size of your face! It’s part of an arboreal group called tiger spiders, which are indigenous to India and Sri Lanka. A dead male specimen of P. rajaei—which is distinguished from other tiger spiders by the markings on its legs and abdomen—was first presented to scientists in October 2009 by a local villager; a survey of the area revealed enough females and juveniles that scientists are confident they've found a new species. “They are quite rare,” Ranil Nanayakkara, co-founder of Sri Lanka’s Biodiversity Education and Research, told WIRED. “They prefer well-established old trees, but due to deforestation the number have dwindled and due to lack of suitable habitat they enter old buildings.” P. rajaei was named after a police officer who helped scientists navigate the area where it was found.

2. Theraphosa blondi

A Goliath bird-eating spider
universoaracnido, Wikimedia Commons // CC BY-SA 2.5

Though Theraphosa blondi is called the Goliath bird-eating spider, it doesn’t actually eat birds. Reportedly, it got its name when an explorer saw it eating a hummingbird, but like other tarantulas, its diet consists mainly of insects, frogs, and rodents. But we’ll forgive you if you’re not comforted by that fact. After all, this spider can have a leg span nearly a foot across—the size of a dinner plate—and weigh up to 6 ounces, making it the largest spider in the world by mass. Its fangs, up to an inch long, can break human skin. (Though venomous, its poison won't bring down a human.) Native to South America, the spider makes noise by rubbing the bristles on its legs together; the sound can be heard up to 15 feet away.

3. Heteropoda maxima

A Heteropoda maxima spider
Petra & Wilifried, Flickr // CC BY 2.0

Yet another reason to avoid dark caverns: Discovered in a cave in Laos in 2011, the giant huntsman spider has a leg span of 12 inches. It’s just one of over 1000 species of huntsman spider. These speedy arachnids can chase down their prey with ease and have legs that extend forward, like a crab’s.

4. Golden silk orb-weavers

These arachnids, of the genus Nephila, have a fearsome relative: the largest fossilized spider ever found is an ancestor. Females of this group of spiders, which are found around the world, can have leg spans up to 6 inches (the males are smaller). Though these orb-weavers typically eat large insects, in Australia, some of these spiders have been snapped eating snakes and birds that got caught in their strong, 5-foot-diameter webs.

5. Phoneutria nigriventer

Sure, Phoneutria nigriventer's nearly 6-inch leg span is scary—but there's something else about this spider that makes it even more terrifying: its venom, a neurotoxin that can be fatal to humans. In fact, along with P. fera, this spider is the most toxic on Earth (thankfully, a good antivenom exists). Native to Central and South America, P. nigriventer is also called the Brazilian wandering spider, for its tendency to roam the forest at night, and the banana spider, both because it hides in banana plants during the day and sometimes stows away in shipments of the fruit. When threatened, the spider lifts its front two pairs of legs and sways side to side, as you can see in the video above.

This story originally appeared in 2013.

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