Chronic Pain Happens Differently in Men and Women

iStock.com/PeopleImages
iStock.com/PeopleImages

Women often feel colder than men due to physical differences. Now, a new study shows that the two sexes have different biological processes underlying a specific kind of pain, too. As WIRED reports, research published in the journal Brain revealed that different cells and proteins were activated in men and women with neuropathic pain—a condition that is often chronic, with symptoms including a burning or shooting sensation. While scientists say further research is needed, these findings could potentially change the way we treat conditions involving chronic pain.

A team of Texas-based neurologists and neuroscientists looked for RNA expressions in the sensory neurons of spinal tumors that had been removed from eight women and 18 men. Some of the patients had pain as a result of nerve compression, while others had not experienced any chronic pain. While studying the neurons of women with pain, researchers noticed that protein-like molecules called neuropeptides, which modulate neurons, were highly activated. For the men, immune system cells called macrophages were most active.

"This represents the first direct human evidence that pain seems to be as sex-dependent in its underlying biology in humans as we have been suggesting for a while now, based on experiments in mice," Jeffrey Mogil, a professor of pain studies at Montreal's McGill University, who was not involved in the Brain study, tells WIRED.

So what exactly do these new findings mean for sufferers of chronic pain? Considering that clinical trials and drug manufacturers have traditionally failed to distinguish between the sexes when it comes to developing pain medication, the study could potentially form a foundation for sex-specific pain therapies that could prove more effective. This might be especially promising for women, who are more likely to have some condition that cause persistent pain, such as migraines or fibromyalgia.

"I think that 10 years from now, when I look back at how papers I've published have had an impact, this one will stick out," Dr. Ted Price, a neuroscience professor and one of the paper's authors, said in a statement. "I hope by then that we are designing clinical trials better considering sex as a biological variable, and that we understand how chronic pain is driven differently in men and women."

[h/t WIRED]

These ASMR-Ready Headphones Promise to Lull You to Sleep

AcousticSheep
AcousticSheep

What do hushed whispers, gently tapping fingernails, and Bob Ross’s voice have in common? They’re all examples of triggers that may cause what’s known as an autonomous sensory meridian response (ASMR), or, as Dictionary.com succinctly explains it, a “calming, pleasurable feeling often accompanied by a tingling sensation” that can be triggered by soothing stimuli. ASMR has recently been recognized as an effective relaxation technique for those looking to calm their nerves; now, ASMR enthusiasts and novices alike can experience it in the form of a sleep-ready headband.

Upon first glance, SleepPhones: ASMR Edition may look like just a fabric headband, but the device actually features flat speakers tucked into soft, stretchy, eco-friendly material. Unlike regular headphones, SleepPhones can be worn comfortably to bed, even if you sleep on your side, and they come preloaded with content designed to help you relax. They feature eight hours of built-in ASMR content by 16 different ASMR artists (or ASMRtists), including but not limited to tracks with rhythmic tapping and "peaceful Italian whisperings."

A close-up of the SleepPhones speaker technology
AcousticSheep

The speaker components of SleepPhones
AcousticSheep

Using SleepPhones is designed to be a stress-free experience. The speakers have the ability to play for 20 ad-free hours with a mere three-hour charging time in between. There are also zero cords involved, meaning you won’t get all tangled up as you lie down or if you have a tendency to toss and turn at night. The small button located in the back of the headband allows you to start, pause, or skip tracks and control the volume.

For people looking for ways to relax beyond yoga and meditation, ASMR may be the way to go. One study observed that subjects watching ASMR videos not only reported feeling that aforementioned pleasant tingling, but were also found to have reduced heart rates.

You can get a pair of your own SleepPhones on Kickstarter with a pledge of $75 or more. They come in three different sizes with seven colors from which to choose.

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FDA Is Warning Against Fecal Transplants After Person Dies From E. Coli Infection

iStock/artisteer
iStock/artisteer

Though it may sound gross, the benefits of a fecal transplant—taking the feces of one person and introducing it into the gastrointestinal tract of another—are promising for those suffering from a Clostridioides difficile infection. The tenacious infections are often the result of sustained antibiotic use, which can kill the patient's "good" gut bacteria and allow C. difficile to proliferate. As the theory goes, the “good” bacteria in feces transplanted from a healthy person may restore the infected person's microbiome and alleviate symptoms like life-threatening diarrhea.

The treatment, which is not FDA-approved, is risky. The FDA has announced that two people involved in a clinical trial recently received fecal transplants that contained drug-resistant bacteria, with one of them dying as a result.

According to The New York Times, the FDA did not offer details of either case, relating only that both patients were immunocompromised, which is one of the contraindications of receiving the transplant. The stool they received was believed to contain antibiotic-resistant E. coli bacteria.

As a result, the FDA is suspending a number of fecal transplant clinical trials until it can be determined how stool is being tested for contamination with potentially deadly bacteria and why the E. coli was not detected. The stool that infected both patients came from the same donor.

Fecal transplants are considered an experimental treatment for C. difficile infection when first-line treatment like antibiotics are ineffective. The fecal transplant is usually introduced to the digestive tract via pills or an infusion.

[h/t The New York Times]

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