Patrick Manson, the Man Who First Linked Mosquitoes to Disease

Mosquitoes are very good at transmitting disease, whether it’s the Zika virus dominating current global health news or the age-old malaria that has killed billions of people over the course of human history.

It wasn’t known that mosquitoes could be dangerous, however, until the late 1870s, when a Scotsman practicing medicine in the Far East discovered that these insects can host parasites that cause human illness. His name was Patrick Manson.

Born near Aberdeen, Scotland in 1844, as a teenager Manson was apprenticed to an ironsmith, but he didn’t have a sturdy enough build to accommodate rigorous manual labor. Instead, he began medical school at the University of Aberdeen. After graduation, he worked at a mental asylum before heading across the world in 1866 to work as a port surgeon for the Imperial Chinese Customs Service in Formosa (present-day Taiwan). He was later transferred to Amoy on China’s southeast coast, where he operated on tumors and encountered a condition that fascinated him: elephantiasis.

At the time, the disease—which can be incapacitating and severely disfiguring, swelling soft tissues to colossal proportions and thickening skin—was leading people to suicide. Aside from having their social lives ruined, many were rendered unable to work. Their families often suspected them of demonic possession, owing to their drastic, horrifying change in appearance.

In 1875 Manson went to London, where he married Henrietta Isabella Thurburn, the 18-year-old daughter of a Royal Navy captain, before bringing his new bride back to Amoy with him the following year. And during his year in London, Manson did more than get married. He also frequented the British Museum’s reading room, where he researched the elephantiasis condition that was plaguing so many people on the other side of the planet.

After returning to his post in South China, Manson investigated the life-cycle of the filarial worm that was just then being established as the cause of elephantiasis. In 1877, he conducted experiments on his gardener, who was infected with the worm. The doctor had mosquitoes feed on the man while he slept, and then dissected the insects after they’d engorged themselves on the gardener’s blood.

Patrick Manson experimenting with filaria sanguinis-hominis on a human subject in China. Image credit: Wikimedia // CC BY 4.0

 
Observing the mosquitoes’ stomach contents under the microscope, Manson saw that the filarial parasites developed further in their life cycle than they did inside a human. Over the course of several days, the parasites beneath his microscope had transformed from “structureless filaria embryos into morphologically distinct larvae,” writes Douglas M. Haynes in his book Imperial Medicine: Patrick Manson and the Conquest of Tropical Disease.

Based on these observations, Manson arrived at the realization that mosquitoes serve as an incubator for parasites and an intermediary mechanism for passing them on to humans (although he didn't understand exactly how the parasite was passed—he thought that the mosquitoes transferred the parasite to water that was then drunk by humans).

He published his findings in medical journals both in China and in the UK. The medical communities in both places needed a wakeup call about mosquitoes—a main reason why much of Asia was sometimes called, at the time, the “white man’s grave.” Of course, people from all backgrounds were and are at serious risk from mosquito-borne illnesses (malaria alone killed an estimated 438,000 people in 2015, according to the World Health Organization), since the insects are very adept at introducing themselves to the human body, often unnoticed. They’re also nifty at traveling (some species can cover multiple miles), making them particularly effective—both medically and geographically—at spreading diseases.

In 1883, Manson moved to Hong Kong, where he founded the Hong Kong College of Medicine. By the end of the 1880s, having spent most of the previous 23 years in the Far East, he returned to the UK. At that point, other doctors and scientists in the Far East were continuing his work on mosquito-borne diseases.

Manson’s breakthrough with filarial parasites—showing that mosquitoes could be a disease vector for humans—formed the basis of modern tropical medicine and paved the way for the theory that mosquitoes transmit malaria. The mosquito-malaria theory would be proven in 1898 by Ronald Ross, who had been mentored by Manson, and who wrote to him: “What a beautiful discovery this is. I can venture to praise it because it belongs to you, not to me.”

The relationship between the two men would eventually become difficult. When Ross won the Nobel Prize in Physiology or Medicine in 1902, the presentation speech and Ross’s own Nobel lecture praised Manson’s influence. But soon after, Manson and Ross’s relationship soured as Ross felt that Manson wasn’t supportive enough in Ross’s disputes with other researchers. The many letters between these two ambitious, brilliant men are anthologized in The beast in the mosquito: the correspondence of Ronald Ross and Patrick Manson.

Though Manson was a Nobel nominee multiple times, he never won the prize. He was, however, knighted in 1903, if that provided any consolation. He continued his work, lecturing on tropical diseases and serving as Chief Medical Officer to the British Colonial Office. He also established the London School of Tropical Medicine, which lives on today as one of the world’s leading institutions for the study of infectious diseases.

In the opening years of the 20th century, Manson’s health began to decline as he was beset by a mix of gout and arthritis. He retired in 1912, at age 68, a self-described “permanent cripple,” whose “next attack of gout will floor [him] altogether.”

He collected honorary memberships from medical societies scattered across the globe until his death in London in 1922 at age 77. Even today, he is referred to as “The Father of Tropical Medicine.”

Marshall McLuhan, the Man Who Predicted the Internet in 1962

Futurists of the 20th century were prone to some highly optimistic predictions. Theorists thought we might be extending our life spans to 150, working fewer hours, and operating private aircrafts from our homes. No one seemed to imagine we’d be communicating with smiley faces and poop emojis in place of words.

Marshall McLuhan didn’t call that either, but he did come closer than most to imagining our current technology-led environment. In 1962, the author and media theorist, predicted we’d have an internet.

That was the year McLuhan, a professor of English born in Edmonton, Canada on this day in 1911, wrote a book called The Gutenberg Galaxy. In it, he observed that human history could be partitioned into four distinct chapters: The acoustic age, the literary age, the print age, and the then-emerging electronic age. McLuhan believed this new frontier would be home to what he dubbed a “global village”—a space where technology spread information to anyone and everyone.

Computers, McLuhan said, “could enhance retrieval, obsolesce mass library organization,” and offer “speedily tailored data.”

McLuhan elaborated on the idea in his 1962 book, Understanding Media, writing:

"Since the inception of the telegraph and radio, the globe has contracted, spatially, into a single large village. Tribalism is our only resource since the electro-magnetic discovery. Moving from print to electronic media we have given up an eye for an ear."

But McLuhan didn’t concern himself solely with the advantages of a network. He cautioned that a surrender to “private manipulation” would limit the scope of our information based on what advertisers and others choose for users to see.

Marshall McLuhan died on December 31, 1980, several years before he was able to witness first-hand how his predictions were coming to fruition.

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Harris and Ewing, Library of Congress
14 Facts About Margaret Sanger
Harris and Ewing, Library of Congress
Harris and Ewing, Library of Congress

Born in 1879, activist Margaret Sanger sparked both revolution and controversy when she began pushing for legalized access to birth control and founded the Planned Parenthood Federation of America. Sanger remains a controversial figure even today, more than 50 years after her death.

1. SHE BLAMED HER FATHER FOR HER MOTHER'S DEATH.

Sanger was born Margaret Louise Higgins, the sixth of 11 children. Her mother, Anne Purcell Higgins, also had seven miscarriages, for a grand total of 18 pregnancies within 22 years. She suffered from poor health for much of that time, and when Anne died of tuberculosis at age 50, Margaret was just 19 years old. According to TIME Magazine, Margaret confronted her father at her mother's coffin and said, "You caused this. Mother is dead from having too many children."

2. SHE WANTED TO BE A DOCTOR.

Margaret Sanger sitting at a table.
Harris and Ewing, Library of Congress

Sadly, medical school was too expensive, so instead she entered a probationary nursing program in 1900. In early 1902, she met architect William Sanger. The two got married later that year and moved to Hastings-on-Hudson, New York, a suburb about 20 miles away from New York City. They had three children.

3. HER HOUSE CAUGHT FIRE, LEADING HER TO MOVE TO THE CITY.

After the Sangers' house in Hastings-on-Hudson caught fire, Sanger stopped enjoying life in the suburbs. By 1911 the couple had decided to start a new life in Greenwich Village, where Sanger joined the Women's Committee of the New York Socialist Party. There, she met fellow radicals and reformers—like novelist Upton Sinclair, anarchist Emma Goldman, art patron Mabel Dodge Luhan, and intellectual Max Eastman—who supported her ambitions to help working women.

In New York City, Sanger decided to jump back into her career by working as a visiting nurse in the Lower East Side tenements. She often treated women who attempted to give themselves abortions because they didn't have the money to care for another child. Dismayed by the poor health and poverty she saw among immigrants there, she developed opinions that would later lead to her advocacy for birth control.

4. SHE BELIEVED BIRTH CONTROL WAS A FREE SPEECH ISSUE.

Soon after arriving in Greenwich Village, Sanger began writing sex education columns for the New York Call, a socialist newspaper. Her frank discussion of women's sexuality and reproduction offended some readers. In 1913, politician and post office official Anthony Comstock censored her column because he considered her usage of words like syphilis and gonorrhea too vulgar.

A year after her column in the New York Call was banned, Sanger launched The Woman Rebel, an eight-page monthly newsletter advocating contraceptive use. Operating under the slogan "No gods, no masters," Sanger used the newsletter to openly defy Comstock's eponymous 1873 laws. (The Comstock laws made it illegal to use the United States Postal Service to send anything containing information about contraceptives or anything else deemed obscene.) She was indicted in August 1914, but she fled to Europe to avoid arrest. She would eventually return to the United States to face trial, but in February 1916 the prosecution dropped the charges.

5. SHE WAS AGAINST ABORTION.

Despite her advocacy for family limitation, Sanger disliked the idea of abortion. She believed proper education and legalized contraceptives would reduce the need for the procedure. In her 1938 autobiography, Sanger described her experience treating Sadie Sachs, one of the women in the East Side tenements. In 1912, Sachs's husband called for Sanger's help after he found Sachs unconscious from a self-induced abortion. After three weeks of treatment from both Sanger and a local doctor, the only advice the doctor could offer Sachs was to avoid "any more such capers" and have her husband sleep on the roof.

Three months later, Sachs became comatose from another self-induced abortion, and Sachs's husband again reached out to Sanger for help. The woman died within 10 minutes of Sanger's arrival. Frustrated by the lack of resources and information available to lower-class women, Sanger resolved to make changes. From that time forward, she wrote, she wanted to "do something to change the destiny of mothers whose miseries were as vast as the skies."

6. SHE POPULARIZED THE TERM BIRTH CONTROL.

Sanger is often credited for coining the term, but that honor actually goes to Robert Parker, a friend of hers who helped create The Woman Rebel. In her 1979 biography on Sanger, author Madeline Gray described Parker as a polio victim who studied yoga with the hopes of gaining more control over his partly paralyzed hand. Gray wrote:

"It occurred to him that control might apply to birth as well. 'Birth control,' he mused. 'Birth control … I think I like it.' They all liked it. As they put on their hats and left, they agreed that birth control was the best name for the movement."

Otto Bobsien, another of Sanger's colleagues, was the first to use the term to proclaim the start of the Birth Control League of America, a new organization he later said "never had more than a nominal existence." In 1915, when Sanger was away in Europe, Bobsien joined the National Birth Control League and offered the fledgling organization use of the movement's new name. When Sanger returned from Europe later that year, she helped popularize the term, considering it more straightforward than phrases like "family limitation."

7. SHE OPENED THE FIRST BIRTH CONTROL CLINIC IN THE U.S.

Historical image of Margaret Sanger standing on a street in New York City
Sanger outside of her trial on January 30, 1917.
Bain News Service, Library of Congress

In October 1916, Margaret Sanger opened a birth control clinic in Brooklyn with the help of her sister, Ethel Byrne, and interpreter Fania Mindell. It was the first of its kind in the U.S., and she modeled it after a Dutch clinic she had visited while evading American police. In the Netherlands, Sanger had learned about pessaries and diaphragms and became convinced they were more effective than the suppositories and douches she promoted in the United States. Sanger brought that new knowledge to her Brooklyn clinic, which served more than 100 women on its first day. For a cover charge of 10 cents, Sanger gave every woman a pamphlet of her New York Call column on "What Every Girl Should Know," a lecture on the female reproductive system, and instructions on several types of contraceptive use. The clinic closed just nine days later when Sanger was once again arrested for violating the Comstock laws. Sanger immediately attempted to reopen the clinic after being released on bail, but, as she wrote, she was promptly re-arrested and charged as a public nuisance.

8. SHE ONCE TOLD A JUDGE SHE COULDN'T RESPECT EXISTING LAWS.

Sanger and Byrne's court trials began in January 1917. Sanger's sister was tried first and sentenced to 30 days in a workhouse, but she immediately went on a hunger strike; Byrne fasted for a week before being force-fed by prison staff. When Sanger went to trial on January 29, she was supported in court by several Greenwich Village socialites and about 50 of the women she'd treated in the Brooklyn clinic. Presiding Justice John J. Freschi offered her a lenient sentence if she promised to obey the law, but Sanger responded by saying, "I cannot respect the law as it exists today." Sanger was found guilty and Freschi also sentenced her to 30 days in a prison workhouse.

In 1918, Sanger appealed the court decision and won a victory for the birth control movement. Although the court upheld Sanger's conviction and she still had to serve her 30 day sentence, Judge Frederick E. Crane of the New York Court of Appeals also ruled that doctors could prescribe contraceptives and disseminate information about birth control under certain conditions. Sanger ran with the new loophole in 1923, when she established a new clinic staffed largely by female doctors. The new clinic operated alongside the American Birth Control League. Almost two decades later, in 1939, the league and the clinic merged, forming the Birth Control Federation of America, and in 1942 this new organization officially became known as the Planned Parenthood Federation of America.

9. THE ROCKEFELLERS ANONYMOUSLY SUPPORTED HER CAUSE.

In the mid-1920s, John D. Rockefeller Jr. anonymously donated $10,000 to the American Birth Control League to fund research into contraceptives. Rockefeller's son, John D. Rockefeller III, continued his father's early support of Sanger's work, albeit more publicly. The Rockefeller Brothers Fund donated money to Planned Parenthood until 1981, when it decided to start funding agricultural research—which was decidedly less controversial—instead.

10. LIKE MANY WELL-KNOWN INTELLECTUALS OF HER DAY, SANGER SUPPORTED EUGENICS.

Many historians believe Sanger's support of eugenics was part strategic and part ideological. Sir Francis Galton, a cousin of Charles Darwin's, initiated the Western eugenics movement by suggesting that traits like "talent and character" could be passed down to children through intentional breeding. Several British and American academics latched onto the idea, including figures like Theodore Roosevelt, John D. Rockefeller Jr., and Alexander Graham Bell. Sanger's support for sterilizing the diseased and "feebleminded" legitimized the birth control movement by aligning her ideas with those of contemporary intellectuals.

Sanger's belief in eugenics was a little different from other intellectuals', though. Eugenicists, she said, believed a woman's first duty should be to the state, and that all "fit" women should bear children. Sanger, on the other hand, thought a woman's first duty should be to herself. She contended the primary reason for birth control was to prevent pregnancies among women who couldn't support a child financially. Sanger believed her ideal of economic eugenics was morally superior to the views posed by traditional eugenicists.

The modern-day Planned Parenthood doesn’t hide Sanger's controversial support of the eugenics movement, but it doesn't endorse it, either. In a document published in 2016 [PDF], the organization said, "We believe that [those ideas] are wrong. Furthermore, we hope that this acknowledgement fosters an open conversation on racism and ableism—both inside and out of our organization."

11. HER BOOKS WERE AMONG THE FIRST BURNED BY NAZIS.

In May 1933, Nazis sanctioned the burning of more than 25,000 books deemed "un-German." Sanger had published at least nine books by that point, and they were all among that number, as were titles by Jack London, Ernest Hemingway, Sigmund Freud, Albert Einstein, and dozens of others. Sanger's books, which advocated for women's choice in everything from childbirth to politics, directly contradicted everything the Third Reich believed. Adolf Hitler supported traditional gender roles and wanted to maintain high birth rates, ideas Sanger decried in her books.

12. HER NIECE WAS PART OF THE INSPIRATION FOR WONDER WOMAN.

A panel of a Wonder Woman comic from 1978.
Tom Simpson, Flickr // CC BY-NC-ND 2.0

Olive Byrne, Sanger's niece, was involved in a polyamorous relationship with Wonder Woman creator William Moulton Marston and his wife, Elizabeth Holloway Marston. Marston credited both Olive and Elizabeth as his muses, according to historian Jill Lepore. In her 2014 book The Secret History of Wonder Woman, Lepore wrote that Marston based part of Wonder Woman's costume on the silver bracelets Olive often wore. Lepore also suggested Sanger herself may have been an influence on the popular comic book character. Feminist movements in the early 1900s often symbolized female oppression with chains, and Sanger was quick to adopt such symbolism with books like Motherhood in Bondage. Wonder Woman's use of chains and ropes as weapons echoed Sanger's vision for female liberation.

13. SHE WAS NOMINATED FOR THE NOBEL PEACE PRIZE 31 TIMES.

Margaret Sanger received 31 nominations for the Nobel Peace Prize between 1953 and 1963. In 1960 alone, she received 20 nominations from 16 university professors and four members of India's parliament (Sanger took several trips to India, where she worked with people like Gandhi to discuss birth control).

14. SHE LIVED JUST LONG ENOUGH TO SEE HER LIFE'S WORK COME TO FRUITION.

Planned Parenthood's publicity director looks over a poster in 1967.
H. William Tetlow, Fox Photos/Getty Images

Two important legal milestones happened after Sanger founded the American Birth Control League in 1921. In December 1936, the 2nd U.S. Circuit Court of Appeals effectively overturned all federal restrictions on birth control, making it legal for doctors throughout the United States to provide access to contraception. On the state level, contraception was legal in some form or another everywhere except Connecticut, Mississippi, and Massachusetts. In 1965, Griswold v. Connecticut overturned the state laws preventing married women from accessing birth control. Griswold v. Connecticut later served as precedent for cases like Eisenstadt v. Baird (1972), which gave unmarried couples unrestricted access to contraception; Roe v. Wade (1973), which legalized abortion; and Carey v. Population Services International (1977), which made it legal for doctors and pharmacists to distribute contraceptives to minors.

Sanger died on September 6, 1966, about a year after the Supreme Court decided on Griswold v. Connecticut. The next day, Alaska Senator Ernest Gruening spoke about Sanger in Congress. In an address to the president, Gruening said Sanger was "a great woman, a courageous and indomitable person who lived to see one of the most remarkable revolutions of modern times—a revolution which her torch kindled."

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